DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes

W. Dougherty, Gerard; T. Loges, Niki; A. Klinkenbusch, Judith; Olbrich, Heike; Pennekamp, Petra; Menchen, Tabea; Raidt, Johanna; Wallmeier, Julia; Werner, Claudius; Westermann, Cordula; Rückert, Christian; Mirra, Virginia; Hjeij, Rim; Memari, Yasin; Durbin, Richard; Kolb‐Kokocinski, Anja; Praveen, Kavita; Amin Kashef, Mohammad; Kashef, Sara; Eghtedari, Fardin; Häffner, Karsten; Valmari, Pekka; Baktai, G; Aviram, Micha; Bentur, Lea; Amirav, Israel; E. Davis, Erica; Katsanis, Nicholas; Brueckner, Martina; Shaposhnykov, Artem; Pigino, Gaia; Dworniczak, Bernd; Omran, Heymut

doi:10.1165/rcmb.2015-0353oc

Public

DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes

Published in American Journal of Respiratory Cell and Molecular Biology • Feb 24, 2016

Authors:

Gerard W. Dougherty

Niki T. Loges

Judith A. Klinkenbusch

Abstract

Primary ciliary dyskinesia (PCD) is a recessively inherited disease that leads to chronic respiratory disorders owing to impaired mucociliary clearance. Conventional transmission electron microscopy (TEM) is a diagnostic standard to identify ultrastructural defects in respiratory cilia but is not us...

Subject

Cilium

Dynein

Respiratory system

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