In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

Christian Cederberg Helms, Hans; Joan Abbott, N.; Burek, Małgorzata; Cecchelli, Roméo; Couraud, Pierre–Olivier; A. Deli, Mária; Y. Förster, Carola; Galla, H.‐J.; A. Romero, Ignacio; V. Shusta, Eric; J. Stebbins, Matthew; Vandenhaute, Elodie; Weksler, Babette; Brodin, Birger

doi:10.1177/0271678x16630991

Public

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

Published in Journal of Cerebral Blood Flow & Metabolism • Feb 11, 2016

Authors:

Hans Christian Cederberg Helms

N. Joan Abbott

Małgorzata Burek

Abstract

The endothelial cells lining the brain capillaries separate the blood from the brain parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial interface for exchange of nutrients, gases, and metabolites between blood and brain, and as a barrier for neurotoxic components...

Subject

Blood–brain barrier

Endothelial stem cell

Parenchyma

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