Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation

Cusin, Cristina; F. Ionescu, Dawn; J. Pavone, Kara; Akeju, Oluwaseun; Cassano, Paolo; E. Taylor, Norman; Eikermann, Matthias; Durham, Kelley; B. Swee, Michaela; Chang, Trina; Dording, Christina; P. Soskin, David; M. Kelley, John; Mischoulon, David; N. Brown, Emery; Fava, Maurizio

doi:10.1177/0004867416631828

Public

Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation

Published in Australian & New Zealand Journal of Psychiatry • Feb 18, 2016

Authors:

Cristina Cusin

Dawn F. Ionescu

Kara J. Pavone

Abstract

OBJECTIVE: Preliminary evidence supports the safety and efficacy of subanesthetic ketamine as an experimental antidepressant, although its effects are often not sustained beyond one week. Studies are lacking that have examined the sustained effects of escalating ketamine doses as augmentation in out...

Subject

Ketamine

Medicine

Anesthesia

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