Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab

Martens, Alexander; Wistuba‐Hamprecht, Kilian; Geukes Foppen, Marnix; Yuan, Jianda; A. Postow, Michael; Wong, Phillip; Romano, Emanuela; Khammari, Amir; Dréno, Brigitte; Capone, Mariaelena; A. Ascierto, Paolo; Maria Di Giacomo, Anna; Maio, Michele; Schilling, Bastian; Sucker, Antje; Schadendorf, Dirk; C. Hassel, Jessica; Eigentler, Thomas; Martus, Peter; D. Wolchok, Jedd; U. Blank, Christian; Pawelec, Graham; Garbe, Claus; Weide, Benjamin

doi:10.1158/1078-0432.ccr-15-2412

Public

Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab

Published in Clinical Cancer Research • Jan 19, 2016

Authors:

Alexander Martens

Kilian Wistuba‐Hamprecht

Marnix Geukes Foppen

Abstract

PURPOSE: To identify baseline peripheral blood biomarkers associated with clinical outcome following ipilimumab treatment in advanced melanoma patients. EXPERIMENTAL DESIGN: Frequencies of myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg), serum lactate dehydrogenase (LDH), routi...

Subject

Ipilimumab

Medicine

Oncology

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