Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

Zhou, Shao‐Lai; Zhou, Zheng‐Jun; Hu, Zhiqiang; Huang, Xiaowu; Wang, Zheng; Chen, Erbao; Fan, Jia; Cao, Ya; Dai, Zhi; Zhou, Jian

doi:10.1053/j.gastro.2016.02.040

Public

Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

Published in Gastroenterology • Feb 27, 2016

Authors:

Shao‐Lai Zhou

Zheng‐Jun Zhou

Zhiqiang Hu

Abstract

Background & AimsNeutrophils can either promote or inhibit tumor progression, depending on the tumor microenvironment, via release of cytokines. Neither the factors produced by tumor-associated neutrophils (TANs) nor their effects on tumor progression have been characterized. We investigated the rol...

Subject

Sorafenib

Hepatocellular carcinoma

Cancer research

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