Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons.

JA, Black; TR, Cummins; C, Plumpton; YH, Chen; W, Hormuzdiar; JJ, Clare; SG, Waxman

doi:10.1152/jn.1999.82.5.2776

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Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons.

Shared by NobleBlocks on Nov 1, 1999 • 12:00 AM UTC

Authors:

Black JA

Cummins TR

Plumpton C

Abstract

After transection of their axons within the sciatic nerve, DRG neurons become hyperexcitable. Recent studies have demonstrated the emergence of a rapidly repriming tetrodotoxin (TTX)-sensitive sodium current that may account for this hyperexcitability in axotomized small (<27 microm diam) DRG neuron...

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