Upregulation of a Silent Sodium Channel After Peripheral, but not Central, Nerve Injury in DRG Neurons

Black, J.A.; Cummins, Theodore; Plumpton, Christopher; H. Chen, Y.; N. Hormuzdiar, W.; J. Clare, Jeff; G. Waxman, Stephen

doi:10.1152/jn.1999.82.5.2776

Public

Upregulation of a Silent Sodium Channel After Peripheral, but not Central, Nerve Injury in DRG Neurons

Published in Journal of Neurophysiology • Nov 1, 1999

Authors:

J.A. Black

Theodore Cummins

Christopher Plumpton

Abstract

After transection of their axons within the sciatic nerve, DRG neurons become hyperexcitable. Recent studies have demonstrated the emergence of a rapidly repriming tetrodotoxin (TTX)-sensitive sodium current that may account for this hyperexcitability in axotomized small (<27 microm diam) DRG neuron...

Subject

Sodium channel

Axotomy

Sciatic nerve

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