Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

J. Mavrakis, Konstantinos; Robert McDonald, E.; R. Schlabach, Michael; Billy, Eric; R. Hoffman, Gregory; deWeck, Antoine; A. Ruddy, David; Venkatesan, Kavitha; Yu, Jianjun; McAllister, Gregg; Stump, Mark; deBeaumont, Rosalie; Ho, Samuel; Yue, Yingzi; Liu, Yue; Yan-Neale, Yan; Yang, Guizhi; Lin, Fallon; Yin, Hong; Gao, Hui; Randal Kipp, D.; Zhao, Songping; T. McNamara, Joshua; R. Sprague, Elizabeth; Zheng, Bing; Lin, Ying; Shin Cho, Young; Gu, Justin; Crawford, Kenneth; Ciccone, David; C. Vitari, Alberto; Lai, Albert; Capka, Vladimir; Hurov, Kristen; A. Porter, Jeffery; Tallarico, John; Mickanin, Craig; Lees, Emma; Pagliarini, Raymond; Keen, Nicholas; Schmelzle, Tobias; Hofmann, Francesco; Stegmeier, Frank; R. Sellers, William

doi:10.1126/science.aad5944

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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Shared by NobleBlocks on Mar 11, 2016 • 12:00 AM UTC

Authors:

Konstantinos J. Mavrakis

E. Robert McDonald

Michael R. Schlabach

Abstract

Tumors put in a vulnerable position Cancer cells often display alterations in metabolism that help fuel their growth. Such metabolic “rewiring” may also work against the cancer cells, however, by creating new vulnerabilities that can be exploited therapeutically. A variety of human tumors show chang...

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