sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

Suárez‐Calvet, Marc; Kleinberger, Gernot; Ángel Araque Caballero, Miguel; Brendel, Matthias; Rominger, Axel; Alcolea, Daniel; Fortea, Juan; Lleó, Alberto; Blesa, Rafael; Domingo Gispert, Juan; Sánchez‐Valle, Raquel; Antonell, Anna; Rami, Lorena; Luís Molinuevo, José; Brosseron, Frederic; Traschütz, Andreas; T. Heneka, Michael; Struyfs, Hanne; Engelborghs, Sebastiaan; Sleegers, Kristel; Van Broeckhoven, Christine; Zetterberg, Henrik; Nellgård, Bengt; Blennow, Kaj; Crispin, Alexander; Ewers, Michael; Haass, Christian

doi:10.15252/emmm.201506123

Public

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

Published in EMBO Molecular Medicine • Mar 3, 2016

Authors:

Marc Suárez‐Calvet

Gernot Kleinberger

Miguel Ángel Araque Caballero

Abstract

TREM2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of TREM2 are associated with increased risk of Alzheimer's disease (AD). TREM2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a so...

Subject

Microglia

Cerebrospinal fluid

Biomarker

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