New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Lu, Yingchang; R. Day, Felix; Gustafsson, Stefan; L. Buchkovich, Martin; Na, Jianbo; Bataille, Véronique; L. Cousminer, Diana; Dastani, Zari; Drong, Alexander; Esko, Tõnu; M. Evans, David; Falchi, Mario; F. Feitosa, Mary; Ferreira, Teresa; K. Hedman, Åsa; Haring, Robin; G. Hysi, Pirro; M. Iles, Mark; E. Justice, Anne; Kanoni, Stavroula; Lagou, Vasiliki; Li, Rui; Li, Xin; E. Locke, Adam; Chen, Lu; Mägi, Reedik; R. B. Perry, John; H. Pers, Tune; Qi, Qibin; Sanna, Marianna; M. Schmidt, Ellen; R. Scott, William; Shungin, Dmitry; Teumer, Alexander; A. E. Vinkhuyzen, Anna; W. Walker, Ryan; Westra, Harm-Jan; Zhang, Mingfeng; Zhang, Weihua; Zhao, Wei; Zhu, Zhihong; Afzal, Uzma; S. Ahluwalia, Tarunveer; J. L. Bakker, Stephan; Bellis, Claire; Bonnefond, Amélie; Borodulin, Katja; S. Buchman, Aron; Cederholm, Tommy; C. Choh, Audrey; Jin Choi, Hyung; E. Curran, Joanne; de Groot, C.P.G.M.; L. De Jager, Philip; Dhonukshe-Rutten, R.A.M.; W. Enneman, Anke; Eury, Elodie; S. Evans, Daniel; Forsén, Tom; Friedrich, Nele; Fumeron, Frédéric; E. Garcia, Melissa; Gärtner, Simone; Han, Bok‐Ghee; S. Havulinna, Aki; Hayward, Caroline; Hernández, Dena; L. Hillege, Hans; Ittermann, Till; W. Kent, Jack; Kolčić, Ivana; Laatikainen, Tiina; Lahti, Jari; Mateo Leach, Irene; G. Lee, Christine; Lee, Jong‐Young; Liu, Tian; Liu, Youfang; Lobbens, Stéphane; Loh, Marie; Lyytikäinen, Leo‐Pekka; Medina‐Gómez, Carolina; Michaëlsson, Karl; A. Nalls, Mike; M. Nielson, Carrie; Oozageer, Laticia; Pascoe, Laura; Paternoster, Lavinia; Polašek, Ozren; Ripatti, Samuli; A. Sarzynski, Mark; Soo Shin, Chan; Smolej Narančić, Nina; Spira, Dominik; Srikanth, Priya; Steinhagen–Thiessen, Elisabeth; Ju Sung, Yun; M. A. Swart, Karin; Taittonen, Leena; Tanaka, Toshiko; Tikkanen, Emmi; van der Velde, Nathalie; M. van Schoor, Natasja; Verweij, Niek; F. Wright, Alan; Yu, Lei; M. Zmuda, Joseph; Eklund, Niina; Forrester, Terrence; Grarup, Niels; Jackson, Anne; Kristiansson, Kati; Kuulasmaa, Teemu; Kuusisto, Johanna; Lichtner, Peter; Luan, Jian’an; Mahajan, Anubha; Männistö, Satu; D. Palmer, Cameron; S. Ried, Janina; A. Scott, Robert; Stančáková, Alena; J. Wagner, Peter; Demirkan, Ayşe; Döring, Angela; Guðnason, Vilmundur; P. Kiel, Douglas; Kühnel, Brigitte; Mangino, Massimo; McKnight, Barbara; Menni, Cristina; R. O’Connell, Jeffrey; A. Oostra, Ben; R. Shuldiner, Alan; Song, Kijoung; Vandenput, Liesbeth; M. van Duijn, Cornelia; Vollenweider, Péter; C. White, Charles; Boehnke, Michael; Boettcher, Yvonne; S. Cooper, Richard; G. Forouhi, Nita; Gieger, Christian; Grallert, Harald; D. Hingorani, Aroon; Jørgensen, Torben; Jousilahti, Pekka; Kivimäki, Mika; Kumari, Meena; Laakso, Markku; Langenberg, Claudia; Linneberg, Allan; Luke, Amy; A. McKenzie, Colin; Palotie, Aarno; Pedersen, Oluf; Peters, Annette; Strauch, Konstantin; O. Tayo, Bamidele; J. Wareham, Nicholas; A. Bennett, David; Bertram, Lars; Blangero, John; Blüher, Matthias; Bouchard, Claude; Campbell, Harry; H. Cho, Nam; R. Cummings, Steven; A. Czerwinski, Stefan; Demuth, Ilja; Eckardt, Rahel; G. Eriksson, Johan; Ferrucci, Luigi; H. Franco, Oscar; Froguel, Philippe; T. Gansevoort, Ron; Hansen, Torben; B. Harris, Tamara; D. Hastie, Nicholas; Heliövaara, Markku; Hofman, Albert; M. Jordan, Joanne; Jula, Antti; Kähönen, Mika; Kajantie, Eero; Knekt, Paul; Koskinen, Seppo; Kovács, Péter; Lehtimäki, Terho; Lind, Lars; Liu, Ching‐Ti; Orwoll, Eric; Osmond, Clive; Perola, Markus; Përusse, Louis; T. Raitakari, Olli; Rankinen, Tuomo; C. Rao, D.; Rice, Treva; Rivadeneira, Fernando; Rudan, Igor; Salomaa, Veikko; I. A. Sørensen, Thorkild; Stümvoll, Michael; Tönjes, Anke; Towne, Bradford; J. Tranah, Gregory; Tremblay, Angelo; G. Uitterlinden, André; van der Harst, Pim; Vartiainen, Erkki; SA Viikari, Jorma; Vitart, Véronique; Vohl, Marie‐Claude; Völzke, Henry; Walker, Mark; Wallaschofski, Henri; H. Wild, Sarah; F. Wilson, James; Yengo, Loïc; Timothy Bishop, D.; B. Borecki, Ingrid; C. Chambers, John; Adrienne Cupples, L.; Dehghan, Abbas; Deloukas, Panos; Fatemifar, Ghazaleh; S. Fox, Caroline; S. Furey, Terrence; Franke, Lude; Han, Jiali; J. Hunter, David; Karjalainen, Juha; Karpe, Fredrik; C. Kaplan, Robert; S. Kooner, Jaspal; I. McCarthy, Mark; M. Murabito, Joanne; P. Morris, Andrew; Newton‐Bishop, Julia; E. North, Kari; Ohlsson, Claes; K. Ong, Ken; Prokopenko, Inga; Brent Richards, J.; E. Schadt, Eric; D. Spector, Tim; Widén, Elisabeth; J. Willer, Cristen; Yang, Jian; Ingelsson, Erik; L. Mohlke, Karen; N. Hirschhorn, Joel; Andrew Pospisilik, J.; Carola Zillikens, M.; M. Lindgren, Cecilia; O. Kilpeläinen, Tuomas; J. F. Loos, Ruth

doi:10.1038/ncomms10495

Public

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Published in Nature Communications • Feb 1, 2016

Authors:

Yingchang Lu

Felix R. Day

Stefan Gustafsson

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight w...

Subject

Link (geometry)

Disease

Medicine

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