Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

E. Neafsey, Daniel; Juraska, Michal; Bedford, Trevor; Benkeser, David; Valim, Clarissa; Griggs, Allison; Lievens, Marc; Abdulla, Salim; Adjei, Samuel; Agbenyega, Tsiri; Todagbé Agnandji, Sélidji; Aíde, Pedro; Anderson, Scott; Ansong, Daniel; J. Aponte, John; Poku Asante, Kwaku; Bejon, Philip; J. Birkett, Ashley; Bruls, Myriam; M. Connolly, Kristen; D’Alessandro, Umberto; Dobaño, Carlota; Gesase, Samwel; Greenwood, Brian; Grimsby, Jonna; Tinto, Halidou; J. Hamel, Mary; Hoffman, Irving; Kamthunzi, Portia; Kariuki, Simon; G. Kremsner, Peter; Leach, Amanda; Lell, Bertrand; J. Lennon, Niall; Lusingu, John; Marsh, Kevin; Martinson, Francis; T. Molel, Jackson; L. Moss, Eli; Njuguna, Patricia; F. Ockenhouse, Christian; Ogutu, Bernhards; Otieno, Walter; Otieno, Lucas; Otieno, Kephas; Owusu‐Agyei, Seth; J. Park, Daniel; G. Pellé, Karell; Robbins, Dana; Russ, Carsten; M. Ryan, Elizabeth; Sacarlal, Jahit; Sogoloff, Brian; Sorgho, Hermann; Tanner, Marcel; G. Theander, Thor; Valéa, Innocent; K. Volkman, Sarah; Yu, Qing; Lapierre, Didier; W. Birren, Bruce; B. Gilbert, Peter; F. Wirth, Dyann

doi:10.1056/nejmoa1505819

Public

Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

Published in New England Journal of Medicine • Oct 21, 2015

Authors:

Daniel E. Neafsey

Michal Juraska

Trevor Bedford

Abstract

BACKGROUND: The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children. We investigated whether the vaccine efficacy was specific to certain parasite genotypes at the cir...

Subject

Malaria

Malaria vaccine

Diversity (politics)

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