Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses

W. Du, William; Yang, Weining; Chen, Yu; Wu, Zhongkai; Stuart Foster, Francis; Yang, Zhenguo; Li, Xiangmin; B. Yang, Burton

doi:10.1093/eurheartj/ehw001

Public

Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses

Published in European Heart Journal • Feb 11, 2016

Authors:

William W. Du

Weining Yang

Yu Chen

Abstract

AIMS: Circular RNAs are a subclass of non-coding RNAs detected within mammalian cells. This study was designed to test the roles of a circular RNA circ-Foxo3 in senescence using in vitro and in vivo approaches. METHODS AND RESULTS: Using the approaches of molecular and cellular biology, we show that...

Subject

FOXO3

Senescence

Gene silencing

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