Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

McGranahan, Nicholas; J.S. Furness, Andrew; Rosenthal, Rachel; Ramskov, Sofie; Lyngaa, Rikke; Kumar Saini, Sunil; Jamal‐Hanjani, Mariam; A. Wilson, Gareth; J. Birkbak, Nicolai; T. Hiley, Crispin; B.K. Watkins, Thomas; Shafi, Seema; Murugaesu, Nirupa; Mitter, Richard; U. Akarca, Ayse; Linares, Joseph; Marafioti, Teresa; Y. Henry, Jake; M. Van Allen, Eliezer; Miao, Diana; Schilling, Bastian; Schadendorf, Dirk; A. Garraway, Levi; Makarov, Vladimir; A. Rizvi, Naiyer; Snyder, Alexandra; D. Hellmann, Matthew; Merghoub, Taha; D. Wolchok, Jedd; A. Shukla, Sachet; J. Wu, Catherine; S. Peggs, Karl; A. Chan, Timothy; Reker Hadrup, Sine; A. Quezada, Sergio; Swanton, Charles

doi:10.1126/science.aaf1490

Public

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Published in Science • Mar 3, 2016

Authors:

Nicholas McGranahan

Andrew J.S. Furness

Rachel Rosenthal

Abstract

As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of neoantigen intratumor heterogeneity (ITH) on antitumor immunity. Through integrated analysis of ITH and neoantigen burden, we de...

Subject

Blockade

Immune checkpoint

Immune system

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