Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

McGranahan, Nicholas; J. S. Furness, Andrew; Rosenthal, Rachel; Ramskov, Sofie; Lyngaa, Rikke; Kumar Saini, Sunil; Jamal-Hanjani, Mariam; A. Wilson, Gareth; J. Birkbak, Nicolai; T. Hiley, Crispin; B. K. Watkins, Thomas; Shafi, Seema; Murugaesu, Nirupa; Mitter, Richard; U. Akarca, Ayse; Linares, Joseph; Marafioti, Teresa; Y. Henry, Jake; M. Van Allen, Eliezer; Miao, Diana; Schilling, Bastian; Schadendorf, Dirk; A. Garraway, Levi; Makarov, Vladimir; A. Rizvi, Naiyer; Snyder, Alexandra; D. Hellmann, Matthew; Merghoub, Taha; D. Wolchok, Jedd; A. Shukla, Sachet; J. Wu, Catherine; S. Peggs, Karl; A. Chan, Timothy; R. Hadrup, Sine; A. Quezada, Sergio; Swanton, Charles

doi:10.1126/science.aaf1490

Public

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Shared by NobleBlocks on Mar 25, 2016 • 12:00 AM UTC

Authors:

Nicholas McGranahan

Andrew J. S. Furness

Rachel Rosenthal

Abstract

The cellular ancestry of tumor antigens One contributing factor in antitumor immunity is the repertoire of neoantigens created by genetic mutations within tumor cells. Like the corresponding mutations, these neoantigens show intratumoral heterogeneity. Some are present in all tumor cells (clonal), a...

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