Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma

D. Garg, Abhishek; Vandenberk, Lien; Koks, Carolien; Verschuere, Tina; Boon, Louis; Van Gool, Stefaan; Agostinis, Patrizia

doi:10.1126/scitranslmed.aae0105

Public

Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma

Published in Science Translational Medicine • Mar 2, 2016

Authors:

Abhishek D. Garg

Lien Vandenberk

Carolien Koks

Abstract

The promise of dendritic cell (DC)-based immunotherapy has been established by two decades of translational research. Of the four malignancies most targeted with clinical DC immunotherapy, high-grade glioma (HGG) has shown the highest susceptibility. HGG-induced immunosuppression is a roadblock to i...

Subject

Dendritic cell

Glioma

Cell

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