Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease

Marthey, Lysiane; Mateus, Christine; Mussini, Charlotte; Nachury, Maria; Nancey, Stéphane; Grange, Florent; Zallot, Camille; Peyrin‐Biroulet, Laurent; Rahier, Jean‐François; Beauregard, Mario; Mortier, Laurent; Coutzac, Clélia; Soularue, Émilie; Lanoy, Émilie; Kapel, Nathalie; Planchard, David; Chaput, Nathalie; Robert, Caroline; Carbonnel, Franck

doi:10.1093/ecco-jcc/jjv227

Public

Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease

Published in Journal of Crohn s and Colitis • Jan 18, 2016

Authors:

Lysiane Marthey

Christine Mateus

Charlotte Mussini

Abstract

BACKGROUND: Therapeutic monoclonal anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) antibodies are associated with immune-mediated enterocolitis. The aim of this study was to provide a detailed description of this entity. METHODS: We included patients with endoscopic signs of inflammation a...

Subject

Medicine

Enterocolitis

Tremelimumab

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