Hypoglycaemic effect of metformin in genetically obese (<i>fa/fa</i>) rats results from an increased utilization of blood glucose by intestine

Pénicaud, Luc; Hitier, Y; Ferré, Pascal; Girard, J.

doi:10.1042/bj2620881

Public

Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine

Published in Biochemical Journal • Sep 15, 1989

Authors:

Luc Pénicaud

Y Hitier

Pascal Ferré

Abstract

The insulin-resistant obese fa/fa rat is a convenient model in which to study a potential effect of metformin, a biguanide used in the treatment of non-insulin-dependent diabetes, on insulin-mediated glucose utilization. Female fa/fa rats were given metformin orally for 8 days. Studies were performe...

Subject

Metformin

Biguanide

Internal medicine

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