Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta‐mediated neurotoxicity

Falker, Clemens; Hartmann, A.; Guett, Inga; Dohler, Frank; C. Altmeppen, Hermann; Betzel, Christian; Schubert, Robin; Thurm, Dana; Wegwitz, Florian; Joshi, Pooja; Verderio, Claudia; Krasemann, Susanne; Glatzel, Markus

doi:10.1111/jnc.13514

Public

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta‐mediated neurotoxicity

Published in Journal of Neurochemistry • Dec 28, 2015

Authors:

Clemens Falker

A. Hartmann

Inga Guett

Abstract

Alzheimer's disease is a common neurodegenerative, progressive, and fatal disorder. Generation and deposition of amyloid beta (Aβ) peptides associate with its pathogenesis and small soluble Aβ oligomers show the most pronounced neurotoxic effects and correlate with disease initiation and progression...

Subject

Microvesicles

Neurodegeneration

Neurotoxicity

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