MYC regulates the antitumor immune response through CD47 and PD-L1

C. Casey, Stephanie; Tong, Ling; Li, Yulin; Do, Rachel; Walz, Susanne; N. Fitzgerald, Kelly; M. Gouw, Arvin; Baylot, Virginie; Gütgemann, Ines; Eilers, Martin; W. Felsher, Dean

doi:10.1126/science.aac9935

Public

MYC regulates the antitumor immune response through CD47 and PD-L1

Published in Science • Mar 10, 2016

Authors:

Stephanie C. Casey

Ling Tong

Yulin Li

Abstract

The MYC oncogene codes for a transcription factor that is overexpressed in many human cancers. Here we show that MYC regulates the expression of two immune checkpoint proteins on the tumor cell surface: the innate immune regulator CD47 (cluster of differentiation 47) and the adaptive immune checkpoi...

Subject

Immune system

Biology

Oncogene

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