MYC regulates the antitumor immune response through CD47 and PD-L1

C. Casey, Stephanie; Tong, Ling; Li, Yulin; Do, Rachel; Walz, Susanne; N. Fitzgerald, Kelly; M. Gouw, Arvin; Baylot, Virginie; Gütgemann, Ines; Eilers, Martin; W. Felsher, Dean

doi:10.1126/science.aac9935

Public

MYC regulates the antitumor immune response through CD47 and PD-L1

Shared by NobleBlocks on Apr 8, 2016 • 12:00 AM UTC

Authors:

Stephanie C. Casey

Ling Tong

Yulin Li

Abstract

Oncogene control of antitumor immunity Recent clinical success of cancer immunotherapy has intensified interest in how tumors normally evade the immune response. Whether and how oncogenes contribute to this process are not well understood. In a study of mice, Casey et al. found that the MYC oncogene...

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