Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1

Sakanyan, Vehary; Hulin, Philippe; Alves de Sousa, Rodolphe; Aline Oliveira Silva, Viviane; A. Hambardzumyan, A.; Nédellec, Steven; Tomasoni, Christophe; Logé, Cédric; Pineau, Charles; Roussakis, Christos; Fleury, Fabrice; Artaud, Isabelle

doi:10.1038/srep21088

Public

Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1

Published in Scientific Reports • Feb 17, 2016

Authors:

Vehary Sakanyan

Philippe Hulin

Rodolphe Alves de Sousa

Abstract

Activation of cell signaling by reactive chemicals and pollutants is an important issue for human health. It has been shown that lipophilic nitro-benzoxadiazole (NBD) compounds rapidly move across the plasma membrane and enhance Epidermal Growth Factor Receptor (EGFR) tyrosine phosphorylation in can...

Subject

Chemistry

Hydrogen peroxide

Superoxide dismutase

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