Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure

G. Richardson, Paul; Riches, Marcie; A. Kernan, Nancy; A. Brochstein, Joel; Mineishi, Shin; Termuhlen, Amanda; Arai, Sally; A. Grupp, Stephan; C. Guinan, Eva; L. Martin, Paul; Steinbach, Gideon; Krishnan, Amrita; R. Nemecek, Eneida; Giralt, Sergio; E. Rodriguez, Tulio; Duerst, Reggie; Doyle, John; H. Antin, Joseph; R. Smith, Angela; Lehmann, Leslie; E. Champlin, Richard; P. Gillio, Alfred; Bajwa, Rajinder; B. D’Agostino, Ralph; M. Massaro, Joseph; Warren, Diane; Miloslavsky, Maja; Hume, Robin; Iacobelli, Massimo; Nejadnik, Bijan; L. Hannah, Alison; J. Soiffer, Robert

doi:10.1182/blood-2015-10-676924

Public

Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure

Published in Blood • Jan 29, 2016

Authors:

Paul G. Richardson

Marcie Riches

Nancy A. Kernan

Abstract

Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). Untreated hepatic VOD/SOS with multi-organ failure (MOF) is associated with >80% mortality. Defibrotide has shown...

Subject

Defibrotide

Medicine

Hepatic veno-occlusive disease

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