Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

Sissoko, Daouda; Laouenan, Cédric; Folkesson, Elin; M’Lebing, Abdoul-Bing; Beavogui, Abdoul-Habib; Baize, Sylvain; Camara, Alseny-Modet; Maes, Piet; Shepherd, Susan; Danel, Christine; Carazo, Sara; N. Conde, Mamoudou; Gala, Jean‐Luc; Colin, Géraldine; Savini, Hélène; Akoi Boré, Joseph; Le Marcis, Frédéric; Raymond Koundouno, Fara; Petitjean, Frédéric; Lamah, Marie-Claire; Diederich, Sandra; Tounkara, Alexis; Poelart, Geertrui; Berbain, Emmanuel; Dindart, Jean-Michel; Duraffour, Sophie; Lefevre, Annabelle; Leno, Tamba; Peyrouset, Olivier; M. Irenge, Léonid; Bangoura, N’Famara; Palich, Romain; Hinzmann, Julia; Kraus, Annette; Sadou Barry, Thierno; Berette, Sakoba; Bongono, André; Seto Camara, Mohamed; Chanfreau Munoz, Valérie; Doumbouya, Lanciné; Harouna, Souley; Mumbere Kighoma, Patient; Roger Koundouno, Fara; Lolamou, Réné; Moriba Loua, Cécé; Massala, Vincent; Kinda, Moumouni; Provost, Célia; Samake, Nenefing; Sekou, Conde; Soumah, Abdoulaye; Arnould, Isabelle; Saa Komano, Michel; Gustin, Lina; Berutto, Carlotta; Camara, Diarra; Saydou Camara, Fodé; Colpaert, Joliene; Delamou, Léontine; Jansson, Lena; Kourouma, Etienne; Loua, Maurice; Nødtvedt Malme, Kristian; Manfrin, Emma; Maomou, André; Milinouno, Adele; Ombelet, Sien; Youla Sidiboun, Aboubacar; Verreckt, Isabelle; Yombouno, Pauline; Bocquin, Anne; Carbonnelle, Caroline; Carmoi, T.; Frange, Pierre; Mély, Stéphane; Nguyen, Vinh‐Kim; Pannetier, Delphine; Taburet, Anne‐Marie; Tréluyer, Jean‐Marc; Seraphin Kolié, Jacques; Moh, Raoul; Cervantes Gonzalez, Minerva; Kuisma, Eeva; Liedigk, Britta; Ngabo, Didier; Rudolf, Martin; Thom, Ruth; Kerber, Romy; Gabriel, Martin; Di, Antonino; Wölfel, Roman; Badir, Jamal; Bentahir, Mostafa; Deccache, Yann; Dumont, Catherine; Durant, F.; El Bakkouri, Karim; Gasasira Uwamahoro, Marie; Smits, Benjamin; Toufik, Nora; Van Cauwenberghe, Stéphane; Ezzedine, Khaled; D’Ortenzio, Éric; Pizarro, Louis; Etienne, Aurélie; Guedj, Jérémie; Fizet, Alexandra; Barte de Sainte Fare, Eric; Murgue, Bernadette; Tran-Minh, Tuan; Rapp, C.; Piguet, Pascal; Poncin, Marc; Draguez, Bertrand; Allaford Duverger, Thierry; Barbe, Solenne; Baret, Guillaume; Defourny, Isabelle; W. Carroll, Miles; Raoul, Hervé; Augier, Augustin; Eholié, Serge; Yazdanpanah, Yazdan; Lévy‐Marchal, Claire; Antierrens, Annick; Van Herp, Michel; Günther, Stephan; de Lamballerie, Xavier; Keïta, Sakoba; Mentré, France; Anglaret, Xavier; Malvy, Denis; Study Group, JIKI

doi:10.1371/journal.pmed.1001967

Public

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

Published in PLoS Medicine • Mar 1, 2016

Authors:

Daouda Sissoko

Cédric Laouenan

Elin Folkesson

Abstract

BACKGROUND: Ebola virus disease (EVD) is a highly lethal condition for which no specific treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak, the World Health Organization released a short list of drugs suitable for EVD research. Favipiravir, an antiviral devel...

Subject

Favipiravir

Ebola virus

Medicine

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