Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells.

P, Chen; T, Hu; Y, Liang; P, Li; X, Chen; J, Zhang; Y, Ma; Q, Hao; J, Wang; P, Zhang; Y, Zhang; H, Zhao; S, Yang; J, Yu; LS, Jeong; H, Qi; M, Yang; RM, Hoffman; Z, Dong; L, Jia

doi:10.1158/1078-0432.ccr-15-2254

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Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells.

Shared by NobleBlocks on Mar 16, 2016 • 12:00 AM UTC

Authors:

Chen P

Hu T

Liang Y

Abstract

Purpose Targeting the protein neddylation pathway has become an attractive anticancer strategy; however, the role of death receptor-mediated extrinsic apoptosis during treatment remained to be determined.Experimental design The activation of extrinsic apoptosis and its role in MLN4924 treatment of h...

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