Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Li, Defang; Liu, Jin; Guo, Baosheng; Liang, Chao; Dang, Lei; Lü, Cheng; He, Xiaojuan; Yeuk-Siu Cheung, Hilda; Xu, Liang; Lu, Changwei; He, Bing; Liu, Biao; Badshah Shaikh, Atik; Li, Fangfei; Wang, Luyao; Yang, Zhijun; W.T. Au, Doris; Peng, Songlin; Zhang, Zongkang; Zhang, Bao‐Ting; Pan, Xiaohua; Qian, Airong; Shang, Peng; Xiao, Lianbo; Jiang, Baohong; K.C. Wong, Chris; Xu, Jiake; Bian, Zhaoxiang; Liang, Zicai; Guo, De‐an; Zhu, Hailong; Tan, Weihong; Lü, Aiping; Zhang, Ge

doi:10.1038/ncomms10872

Public

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Published in Nature Communications • Mar 7, 2016

Authors:

Defang Li

Jin Liu

Baosheng Guo

Abstract

Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is mostly unknown. Here, we show that increased os...

Subject

Osteoclast

Osteoblast

Ovariectomized rat

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