Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers

Ranki, Tuuli; Pesonen, Sari; Hemminki, Akseli; Partanen, Kaarina; Kairemo, Kalevi; Alanko, Tuomo; Lundin, Johan; Linder, Nina; Turkki, Riku; Ristimäki, Ari; Jäger, Elke; Karbach, Julia; Wahle, Claudia; Kankainen, Matti; Backman, Charlotta; von Euler, Mikael; Haavisto, Elina; Hakonen, Tiina; Heiskanen, Raita; Jäderberg, Magnus; Juhila, Juuso; Priha, Petri; Suoranta, Laura; Vassilev, Lotta; Vuolanto, Antti; Joensuu, Timo

doi:10.1186/s40425-016-0121-5

Public

Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers

Published in Journal for ImmunoTherapy of Cancer • Mar 2, 2016

Authors:

Tuuli Ranki

Sari Pesonen

Akseli Hemminki

Abstract

BACKGROUND: We conducted a phase I study with a granulocyte macrophage colony stimulating factor (GMCSF)-expressing oncolytic adenovirus, ONCOS-102, in patients with solid tumors refractory to available treatments. The objectives of the study were to determine the optimal dose for further use and to...

Subject

Medicine

ELISPOT

Tolerability

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!