BRCA2 regulates DMC1-mediated recombination through the BRC repeats

S. Martinez, Juan; Von Nicolai, Catharina; Kim, Taeho; Ehlén, Åsa; V. Mazin, Alexander; C. Kowalczykowski, Stephen; Carreira, Aura

doi:10.1073/pnas.1601691113

Public

BRCA2 regulates DMC1-mediated recombination through the BRC repeats

Published in Proceedings of the National Academy of Sciences • Mar 14, 2016

Authors:

Juan S. Martinez

Catharina Von Nicolai

Taeho Kim

Abstract

In somatic cells, BRCA2 is needed for RAD51-mediated homologous recombination. The meiosis-specific DNA strand exchange protein, DMC1, promotes the formation of DNA strand invasion products (joint molecules) between homologous molecules in a fashion similar to RAD51. BRCA2 interacts directly with bo...

Subject

RAD51

Homologous recombination

Biology

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