Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Meijer, Laurent; J. Nelson, Deborah; Riazanski, Vladimir; G. Gabdoulkhakova, Aida; Héry-Arnaud, Geneviève; Le Berre, Rozenn; Loaëc, Nadège; Oumata, Nassima; Galons, Hervé; Nowak, Emmanuel; Guéganton, L.; Dorothée, Guillaume; Prochazkova, Michaela; Hall, Bradford; B. Kulkarni, Ashok; D. Gray, Robert; G. Rossi, Adriano; Witko‐Sarsat, Véronique; Norez, Caroline; Becq, Frédéric; Ravel, Denis; Mottier, Dominique; Rault, G.

doi:10.1159/000444256

Public

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Published in Journal of Innate Immunity • Jan 1, 2016

Authors:

Laurent Meijer

Deborah J. Nelson

Vladimir Riazanski

Abstract

(R)-Roscovitine, a pharmacological inhibitor of kinases, is currently in phase II clinical trial as a drug candidate for the treatment of cancers, Cushing's disease and rheumatoid arthritis. We here review the data that support the investigation of (R)-roscovitine as a potential therapeutic agent fo...

Subject

Metabolite

Pharmacology

Chemistry

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