SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Pan, Huize; Guan, Di; Liu, Xiaomeng; Li, Jingyi; Wang, Lixia; Wu, Jun; Zhou, Junzhi; Zhang, Weizhou; Ren, Ruotong; Zhang, Weiqi; Li, Ying; Yang, Jiping; Hao, Ying; Yuan, Tingting; Yuan, Guohong; Wang, Hu; Ju, Zhenyu; Mao, Zhiyong; Li, Jian; Qu, Jing; Tang, Fuchou; Liu, Guang‐Hui

doi:10.1038/cr.2016.4

Public

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Published in Cell Research • Jan 15, 2016

Authors:

Huize Pan

Di Guan

Xiaomeng Liu

Abstract

SIRT6 belongs to the mammalian homologs of Sir2 histone NAD(+)-dependent deacylase family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal tissues. It remains unknown whether human SIRT6 has a direct role in maintaining the homeostasis of mesodermal tissues. To this...

Subject

SIRT6

Cell biology

Transactivation

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