Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon

Kaji, Izumi; Akiba, Yasutada; Konno, Kohtarou; Watanabe, Masahiko; Kimura, Shunsuke; Iwanaga, Toshihiko; Kuri, Ayaka; Iwamoto, Ken‐ichi; Kuwahara, Atsukazu; D. Kaunitz, Jonathan

doi:10.1113/jp271441

Public

Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon

Published in The Journal of Physiology • Feb 8, 2016

Authors:

Izumi Kaji

Yasutada Akiba

Kohtarou Konno

Abstract

KEY POINTS: Luminal short-chain fatty acids (SCFAs) influence gut physiological function via SCFA receptors and transporters. The contribution of an SCFA receptor, free fatty acid receptor (FFA)3, to the enteric nervous system is unknown. FFA3 is expressed in enteric cholinergic neurons. Activation ...

Subject

Vesicular acetylcholine transporter

Cholinergic

Endocrinology

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