Mitochondria-targeted Triphenylamine Derivatives Activatable by Two-Photon Excitation for Triggering and Imaging Cell Apoptosis

Chennoufi, Rahima; Bougherara, Houcine; Gagey‐Eilstein, Nathalie; Dumat, Blaise; Henry, E.; Subra, Frédéric; Bury‐Moné, Stéphanie; Mahuteau‐Betzer, Florence; Tauc, Patrick; Teulade‐Fichou, Marie‐Paule; Deprez, Eric

doi:10.1038/srep21458

Public

Mitochondria-targeted Triphenylamine Derivatives Activatable by Two-Photon Excitation for Triggering and Imaging Cell Apoptosis

Published in Scientific Reports • Mar 7, 2016

Authors:

Rahima Chennoufi

Houcine Bougherara

Nathalie Gagey‐Eilstein

Abstract

Photodynamic therapy (PDT) leads to cell death by using a combination of a photosensitizer and an external light source for the production of lethal doses of reactive oxygen species (ROS). Since a major limitation of PDT is the poor penetration of UV-visible light in tissues, there is a strong need ...

Subject

Programmed cell death

Two-photon excitation microscopy

Reactive oxygen species

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