Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

Grover, Amit; Sanjuán-Pla, Alejandra; Thongjuea, Supat; Carrelha, Joana; Giustacchini, Alice; Rosa Gambardella, Adriana; C. Macaulay, Iain; Mancini, Elena; C. Luís, Tiago; J. Mead, Adam; Eirik W. Jacobsen, Sten; Nerlov, Claus

doi:10.1038/ncomms11075

Public

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

Published in Nature Communications • Mar 24, 2016

Authors:

Amit Grover

Alejandra Sanjuán-Pla

Supat Thongjuea

Abstract

Aged haematopoietic stem cells (HSCs) generate more myeloid cells and fewer lymphoid cells compared with young HSCs, contributing to decreased adaptive immunity in aged individuals. However, it is not known how intrinsic changes to HSCs and shifts in the balance between biased HSC subsets each contr...

Subject

Haematopoiesis

Stem cell

Lymphopoiesis

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