Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

Zhang, Ji‐chun; Yao, Wei; Hashimoto, Kenji

doi:10.2174/1570159x14666160119094646

Public

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

Published in Current Neuropharmacology • Jan 20, 2016

Authors:

Ji‐chun Zhang

Wei Yao

Kenji Hashimoto

Abstract

Depression is the most prevalent and among the most debilitating of psychiatric disorders. The precise neurobiology of this illness is unknown. Several lines of evidence suggest that peripheral and central inflammation plays a role in depressive symptoms, and that anti-inflammatory drugs can improve...

Subject

Tropomyosin receptor kinase B

Neurotrophic factors

Nucleus accumbens

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