Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

Nishimoto, Sachiko; Fukuda, Daiju; Higashikuni, Yasutomi; Tanaka, Kimie; Hirata, Yoichiro; Murata, Chie; Kim‐Kaneyama, Joo‐ri; Sato, Fukiko; Bando, Masahiro; Yagi, Shusuke; Soeki, Takeshi; Hayashi, Tetsuya; Imoto, Issei; Sakaue, Hiroshi; Shimabukuro, Michio; Sata, Masataka

doi:10.1126/sciadv.1501332

Public

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

Published in Science Advances • Mar 4, 2016

Authors:

Sachiko Nishimoto

Daiju Fukuda

Yasutomi Higashikuni

Abstract

Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown. Here we showed that obesity-related adipocyte degeneration causes release of cell-free DNA (cfDNA), which promotes macrophage accumulatio...

Subject

Adipose tissue

Insulin resistance

Internal medicine

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