Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Kettunen, Johannes; Demirkan, Ayşe; Würtz, Peter; H. M. Draisma, Harmen; Haller, Toomas; Rawal, Rajesh; A. M. Vaarhorst, Anika; J. Kangas, Antti; Lyytikäinen, Leo‐Pekka; Pirinen, Matti; Pool, René; Sarin, Antti‐Pekka; Soininen, Pasi; Tukiainen, Taru; Wang, Qin; Tiainen, Mika; Tynkkynen, Tuulia; Amin, Najaf; Zeller, Tanja; Beekman, Marian; Deelen, Joris; Willems van Dijk, Ko; Esko, Tõnu; Hottenga, Jouke‐Jan; M van Leeuwen, Elisabeth; Lehtimäki, Terho; Mihailov, Evelin; J. Rose, Richard; J. M. de Craen, Anton; Gieger, Christian; Kähönen, Mika; Perola, Markus; Blankenberg, Stefan; J. Savolainen, Markku; Verhoeven, Aswin; Viikari, Jorma; Willemsen, Gonneke; I. Boomsma, Dorret; M. van Duijn, Cornelia; G. Eriksson, Johan; Jula, Antti; Järvelin, Marjo‐Riitta; Kaprio, Jaakko; Metspalu, Andres; T. Raitakari, Olli; Salomaa, Veikko; Eline Slagboom, P.; Waldenberger, Mélanie; Ripatti, Samuli; Ala‐Korpela, Mika

doi:10.1038/ncomms11122

Public

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Published in Nature Communications • Mar 23, 2016

Authors:

Johannes Kettunen

Ayşe Demirkan

Peter Würtz

Abstract

Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive molecular profiling of circulating metabolites captures highly heritable traits, which can help to uncover metabolic pathophysiology un...

Subject

Mendelian randomization

Biology

Genome-wide association study

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