Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.

Simon, Stritt,; Paquita, Nurden,; Remi, Favier,; Marie, Favier,; Silvia, Ferioli,; Sanjeev K, Gotru,; Eeuwijk, Judith M M, van; Harald, Schulze,; Alan T, Nurden,; Michele P, Lambert,; Ernest, Turro,; Stephanie, Burger-Stritt,; Masayuki, Matsushita,; Lorenz, Mittermeier,; Paola, Ballerini,; Susanna, Zierler,; Michael A, Laffan,; Vladimir, Chubanov,; Thomas, Gudermann,; Bernhard, Nieswandt,; Attila, Braun,

doi:10.1038/ncomms11097

Public

Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.

Published in Nature communications • Mar 29, 2016

Authors:

Stritt, Simon

Nurden, Paquita

Favier, Remi

Abstract

Mg(2+) plays a vital role in platelet function, but despite implications for life-threatening conditions such as stroke or myocardial infarction, the mechanisms controlling [Mg(2+)]i in megakaryocytes (MKs) and platelets are largely unknown. Transient receptor potential melastatin-like 7 channel (TR...

Subject

Animals

Blood Platelets

Cytoskeleton

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