Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

Giaid, Adel; Saleh, Dina

doi:10.1056/nejm199507273330403

Public

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

Published in New England Journal of Medicine • Jul 27, 1995

Authors:

Adel Giaid

Dina Saleh

Abstract

BACKGROUND: Pulmonary hypertension is characterized by abnormal thickening of the pulmonary arteries and increased pulmonary vascular resistance. Nitric oxide is a potent endothelium-derived vasorelaxant substance and an inhibitor of smooth-muscle-cell growth. Nitric oxide is produced in various cel...

Subject

Nitric oxide

Pulmonary hypertension

Medicine

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