Direct, Metal-Free Amination of Heterocyclic Amides/Ureas with NH-Heterocycles and N-Substituted Anilines in POCl<sub>3</sub>

Deng, Xiaohu; Roessler, Armin; Brdar, Ivana; Faessler, Roger; Wu, Jiejun; S. Sales, Zachary; S. Mani, Neelakandha

doi:10.1021/jo201425q

Public

Direct, Metal-Free Amination of Heterocyclic Amides/Ureas with NH-Heterocycles and N-Substituted Anilines in POCl3

Published in The Journal of Organic Chemistry • Sep 7, 2011

Authors:

Xiaohu Deng

Armin Roessler

Ivana Brdar

Abstract

A POCl(3)-mediated, direct amination reaction of heterocyclic amides/ureas with NH-heterocycles or N-substituted anilines is described. Compared to the existing methods, this operationally simple protocol provides unique reactivity and functional group compatibility because of the metal-free, acidic...

Subject

Chemistry

Amination

Reactivity (psychology)

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