Piperaquine Monotherapy of Drug-Susceptible<i>Plasmodium falciparum</i>Infection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia

Pasay, Cielo; J. Rockett, Rebecca; Sekuloski, Silvana; Griffin, Paul; Marquart, Louise; L. Peatey, Christopher; Wang, Claire; O’Rourke, Peter; Elliott, Suzanne; Baker, Mark; J. Möhrle, Jörg; McCarthy, James

doi:10.1093/infdis/jiw128

Public

Piperaquine Monotherapy of Drug-SusceptiblePlasmodium falciparumInfection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia

Published in The Journal of Infectious Diseases • Apr 7, 2016

Authors:

Cielo Pasay

Rebecca J. Rockett

Silvana Sekuloski

Abstract

BACKGROUND: Piperaquine, coformulated with dihydroartemisinin, is a component of a widely used artemisinin combination therapy. There is a paucity of data on its antimalarial activity as a single agent. Such data, if available, would inform selection of new coformulations. METHODS: We undertook a st...

Subject

Primaquine

Piperaquine

Artemisinin

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