Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

M. Mohiuddin, Muhammad; K. Singh, Avneesh; C. Corcoran, Philip; L. Thomas, Marvin; S. Clark, Tannia; Lewis, Billeta; F. Hoyt, Robert; Eckhaus, Michael; N. Pierson, Richard; J. Belli, Aaron; Wolf, Eckhard; Klymiuk, Nikolai; J. Phelps, Carol; A. Reimann, Keith; Ayares, David; A. Horvath, Keith

doi:10.1038/ncomms11138

Public

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

Published in Nature Communications • Apr 5, 2016

Authors:

Muhammad M. Mohiuddin

Avneesh K. Singh

Philip C. Corcoran

Abstract

Preventing xenograft rejection is one of the greatest challenges of transplantation medicine. Here, we describe a reproducible, long-term survival of cardiac xenografts from alpha 1-3 galactosyltransferase gene knockout pigs, which express human complement regulatory protein CD46 and human thrombomo...

Subject

Antibody

Medicine

Xenotransplantation

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