Antitumor Activity of Thalidomide in Refractory Multiple Myeloma

Singhal, Seema; Mehta, Jayesh; Desikan, Raman; Ayers, Dan; K. Roberson, Paula; Eddlemon, Paul; C. Munshi, Nikhil; Anaissie, Elias; S. Wilson, Carla; V. Dhodapkar, Madhav; B. Zeldis, Jerome; S. Siegel, David; Crowley, John; Barlogie, Bart

doi:10.1056/nejm199911183412102

Public

Antitumor Activity of Thalidomide in Refractory Multiple Myeloma

Published in New England Journal of Medicine • Nov 18, 1999

Authors:

Seema Singhal

Jayesh Mehta

Raman Desikan

Abstract

BACKGROUND: Patients with myeloma who relapse after high-dose chemotherapy have few therapeutic options. Since increased bone marrow vascularity imparts a poor prognosis in myeloma, we evaluated the efficacy of thalidomide, which has antiangiogenic properties, in patients with refractory disease. ME...

Subject

Medicine

Thalidomide

Multiple myeloma

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