Surface Functionalization of TiO<sub>2</sub> Nanotubes with Bone Morphogenetic Protein 2 and Its Synergistic Effect on the Differentiation of Mesenchymal Stem Cells

Lai, Min; Cai, Kaiyong; Li, Zhao; Chen, Xiuyong; Hou, Yanhua; Yang, Zaixiang

doi:10.1021/bm1014365

Public

Surface Functionalization of TiO2 Nanotubes with Bone Morphogenetic Protein 2 and Its Synergistic Effect on the Differentiation of Mesenchymal Stem Cells

Published in Biomacromolecules • Mar 7, 2011

Authors:

Min Lai

Kaiyong Cai

Zhao Li

Abstract

To investigate the influence of surface-functionalized substrates with nanostructures on the behaviors of mesenchymal stem cells, we conjugated bone morphogenetic protein 2 (BMP2) onto TiO(2) nanotubes with different diameter sizes of 30, 60, and 100 nm for in vitro study. Polydopamine was employed ...

Subject

Bone morphogenetic protein 2

Osteopontin

Surface modification

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