Regiodivergent Access to Five- and Six-Membered Benzo-Fused Lactams: Ru-Catalyzed Olefin Hydrocarbamoylation

Li, Bin; Park, Yoonsu; Chang, Sukbok

doi:10.1021/ja411913e

Public

Regiodivergent Access to Five- and Six-Membered Benzo-Fused Lactams: Ru-Catalyzed Olefin Hydrocarbamoylation

Published in Journal of the American Chemical Society • Dec 27, 2013

Authors:

Bin Li

Yoonsu Park

Sukbok Chang

Abstract

We report herein a new strategy of the Ru-catalyzed intramolecular olefin hydrocarbamoylation for the regiodivergent synthesis of five- and six-membered benzo-fused lactams starting from N-(2-alkenylphenyl)formamides. Using a combined catalyst of Ru3(CO)12/Bu4NI in DMSO/toluene cosolvent (catalytic ...

Subject

Chemistry

Catalysis

Regioselectivity

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