Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis

E. Lipsky, Peter; van der Heijde, Désirée; William St. Clair, E.; E. Fürst, Daniel; C. Breedveld, Ferdinand; R. Kalden, Joachim; S Smolen, Josef; H. Weisman, Michael; Emery, Paul; Feldmann, Marc; R. Harriman, Gregory; N. Maini, Ravinder

doi:10.1056/nejm200011303432202

Public

Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis

Published in New England Journal of Medicine • Nov 30, 2000

Authors:

Peter E. Lipsky

Désirée van der Heijde

E. William St. Clair

Abstract

BACKGROUND: Neutralization of tumor necrosis factor a (TNF-alpha) for three to six months reduces the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known. METHODS: We treated 428 patients w...

Subject

Medicine

Infliximab

Rheumatoid arthritis

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