Rapid Detection of a Cocaine-Binding Aptamer Using Biological Nanopores on a Chip

Kawano, Ryuji; Osaki, Toshihisa; Sasaki, Hirotaka; Takinoue, Masahiro; Yoshizawa, Satoko; Takeuchi, Shoji

doi:10.1021/ja2026085

Public

Rapid Detection of a Cocaine-Binding Aptamer Using Biological Nanopores on a Chip

Published in Journal of the American Chemical Society • May 9, 2011

Authors:

Ryuji Kawano

Toshihisa Osaki

Hirotaka Sasaki

Abstract

This paper describes a methodology for the rapid and highly selective detection of cocaine using a membrane protein channel combined with a DNA aptamer. The DNA aptamer recognizes the cocaine molecule with high selectivity. We successfully detected a low concentration of cocaine (300 ng/mL, the drug...

Subject

Aptamer

Chemistry

Detection limit

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