The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance

Dubar, Faustine; J. Egan, Timothy; Pradines, Bruno; J. Kuter, David; K. Ncokazi, Kanyile; Forge, Delphine; Paul, Jean‐François; Pierrot, Christine; Kalamou, Hadidjatou; Khalife, Jamal; Buisine, Eric; Rogier, Christophe; Vezin, Hervé; Forfar, Isabelle; Slomianny, Christian; Trivelli, Xavier; Kapishnikov, Sergey; Leiserowitz, Leslie; Dive, Daniel; Biot, Christophe

doi:10.1021/cb100322v

Public

The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance

Published in ACS Chemical Biology • Dec 16, 2010

Authors:

Faustine Dubar

Timothy J. Egan

Bruno Pradines

Abstract

Inhibition of hemozoin biocrystallization is considered the main mechanism of action of 4-aminoquinoline antimalarials including chloroquine (CQ) but cannot fully explain the activity of ferroquine (FQ) which has been related to redox properties and intramolecular hydrogen bonding. Analogues of FQ, ...

Subject

Intramolecular force

Hydrogen bond

Hemozoin

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!