Hyperinsulinism and Hyperammonemia in Infants with Regulatory Mutations of the Glutamate Dehydrogenase Gene

A. Stanley, Charles; K. Lieu, Yen; Y.L. Hsu, Betty; Burlina, Alberto; R. Greenberg, Cheryl; J. Hopwood, Nancy; Perlman, Kusiel; H. Rich, Barry; Zammarchi, Enrico; Poncz, Mortimer

doi:10.1056/nejm199805073381904

Public

Hyperinsulinism and Hyperammonemia in Infants with Regulatory Mutations of the Glutamate Dehydrogenase Gene

Published in New England Journal of Medicine • May 7, 1998

Authors:

Charles A. Stanley

Yen K. Lieu

Betty Y.L. Hsu

Abstract

BACKGROUND: A new form of congenital hyperinsulinism characterized by hypoglycemia and hyperammonemia was described recently. We hypothesized that this syndrome of hyperinsulinism and hyperammonemia was caused by excessive activity of glutamate dehydrogenase, which oxidizes glutamate to alpha-ketogl...

Subject

Hyperammonemia

Medicine

Hyperinsulinism

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!