Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

R. Bernard, Gordon; Vincent, Jean‐Louis; Laterre, Pierre‐François; P. LaRosa, Steven; Dhainaut, Jean-François; Lopez-Rodriguez, Angel; S. Steingrub, Jay; E. Garber, Gary; D. Helterbrand, Jeffrey; Wesley Ely, E.; J. Fisher, Charles

doi:10.1056/nejm200103083441001

Public

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Published in New England Journal of Medicine • Mar 8, 2001

Authors:

Gordon R. Bernard

Jean‐Louis Vincent

Pierre‐François Laterre

Abstract

BACKGROUND: Drotrecogin alfa (activated), or recombinant human activated protein C, has antithrombotic, antiinflammatory, and profibrinolytic properties. In a previous study, drotrecogin alfa activated produced dose-dependent reductions in the levels of markers of coagulation and inflammation in pat...

Subject

Drotrecogin alfa

Medicine

Placebo

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