Oxidative stress, cell cycle arrest and differentiation contribute toward the antiproliferative action of BSO and calcitriol on Caco-2 cells

C. Liaudat, Ana; Paola Bohl, Luciana; G. Tolosa de Talamoni, Nori; Maletto, Belkys; C. Pistoresi‐Palencia, María; Picotto, Gabriela

doi:10.1097/cad.0000000000000109

Public

Oxidative stress, cell cycle arrest and differentiation contribute toward the antiproliferative action of BSO and calcitriol on Caco-2 cells

Published in Anti-Cancer Drugs • Mar 28, 2014

Authors:

Ana C. Liaudat

Luciana Paola Bohl

Nori G. Tolosa de Talamoni

Abstract

The prognosis and incidence of colon cancer are linked to vitamin D3 serum levels. To evaluate the effects of D,L-buthionine-S,R-sulfoximine (BSO), 1,25(OH)2D3 and their combination on intestinal Caco-2 cell growth, to elucidate the possible cellular mechanisms involved in their antiproliferative ac...

Subject

Chemistry

Superoxide dismutase

Buthionine sulfoximine

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