Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

L. Leonardi, Craig; Matheson, Robert; Zachariae, Claus; S. Cameron, Gregory; Li, Linda; Edson‐Heredia, Emily; Braun, Daniel; Banerjee, Subhashis

doi:10.1056/nejmoa1109997

Public

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

Published in New England Journal of Medicine • Mar 28, 2012

Authors:

Craig L. Leonardi

Robert Matheson

Claus Zachariae

Abstract

BACKGROUND: Type 17 helper T cells have been suggested to play a pathological role in psoriasis. They secrete several proinflammatory cytokines, including interleukin-17A (also known as interleukin-17). We evaluated the safety and efficacy of ixekizumab (LY2439821), a humanized anti-interleukin-17 m...

Subject

Ixekizumab

Plaque psoriasis

Monoclonal antibody

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