Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy

A. Morillo, Carlos; Antônio Marin‐Neto, José; Avezum, Álvaro; Sosa‐Estáni, Sergio; Rassi, Anis; Rosas, Fernando; Villena, Erick; Quiroz, Roberto; Bonilla, Rina; Britto, Constança; Guhl, Felipe; Velázquez, Elsa; Cristina Bonilla Neira, Laura; Meeks, Brandi; Ps, Rao; Pogue, Janice; José Cordeiro Mattos, Antônio; Lazdins, Janis; Rassi, Anis; J. Connolly, Stuart; Yusuf, Salim

doi:10.1056/nejmoa1507574

Public

Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy

Published in New England Journal of Medicine • Sep 1, 2015

Authors:

Carlos A. Morillo

José Antônio Marin‐Neto

Álvaro Avezum

Abstract

BACKGROUND: The role of trypanocidal therapy in patients with established Chagas' cardiomyopathy is unproven. METHODS: We conducted a prospective, multicenter, randomized study involving 2854 patients with Chagas' cardiomyopathy who received benznidazole or placebo for up to 80 days and were followe...

Subject

Benznidazole

Medicine

Internal medicine

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