Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma.

H, Hirata; K, Sugimachi; H, Komatsu; M, Ueda; T, Masuda; R, Uchi; S, Sakimura; S, Nambara; T, Saito; Y, Shinden; T, Iguchi; H, Eguchi; S, Ito; K, Terashima; K, Sakamoto; M, Hirakawa; H, Honda; K, Mimori

doi:10.1158/0008-5472.can-15-2601

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Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma.

Shared by NobleBlocks on Apr 6, 2016 • 12:00 AM UTC

Authors:

Hirata H

Sugimachi K

Komatsu H

Abstract

Fructose-1,6-bisphosphatase (FBP1), the rate-limiting enzyme in gluconeogenesis, is reduced in expression in certain cancers where it has been hypothesized to act as a tumor suppressor, including in hepatocellular carcinoma (HCC). Here, we report functional evidence supporting this hypothesis, provi...

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