Inherited Complete Deficiency of 20-Kilodalton Homologous Restriction Factor (CD59) as a Cause of Paroxysmal Nocturnal Hemoglobinuria

Yamashina, Manabu; Ueda, E; Kinoshita, Taroh; Takami, Tsuyoshi; Ojima, Akitsugu; Ono, Hiromasa; Tanaka, Hiroshi; Kondo, Naomi; Orii, Tadao; Okada, Noriko; Okada, Hidechika; Inoue, Kozo; Kitani, Teruo

doi:10.1056/nejm199010253231707

Public

Inherited Complete Deficiency of 20-Kilodalton Homologous Restriction Factor (CD59) as a Cause of Paroxysmal Nocturnal Hemoglobinuria

Published in New England Journal of Medicine • Oct 25, 1990

Authors:

Manabu Yamashina

E Ueda

Taroh Kinoshita

Abstract

PAROXYSMAL nocturnal hemoglobinuria is a rare acquired disease caused by an unusual susceptibility of erythrocytes to the lytic action of complement. The abnormal erythrocytes are thought to originate from the clonal proliferation of bone marrow progenitors altered by somatic mutation.1 Erythrocytes...

Subject

Paroxysmal nocturnal hemoglobinuria

Hemoglobinuria

Medicine

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